Table 1.
Oncogenic and tumor suppressor Wnts regulating the canonical and the non-canonical Wnt signaling pathways in the pathogenesis of colorectal cancer (CRC).
| Wnts | Expression level | Effect | Type of Wnt signaling |
|---|---|---|---|
| Wnt1 | Decreased (25) | Oncogene | Canonical (26) |
| Increased (27) | Non-canonical (28) | ||
| Wnt2 | Increased (29–31) | Oncogene | Canonical (32) |
| Non-canonical (33) | |||
| Wnt2b | Increased (34) | Oncogene | Canonical (34) |
| Wnt3 | Increased (35) | Oncogene | Canonical (35) |
| Wnt3a | Increased (36) | Oncogene | Canonical (37) |
| Tumor suppressor | Canonical (38) | ||
| Wnt4 | Increased (39) | Oncogene | Canonical (39, 40) |
| Wnt5a | Decreased (41, 42) | Tumor suppressor | Canonical (43) |
| Non-canonical (44) | |||
| Increased (45, 46) | Oncogene | Canonical (47) | |
| Non-canonical (48) | |||
| Wnt5b | Increased (49, 50) | Oncogene | Non-canonical (50) |
| Wnt6 | Increased (51, 52) | Oncogene | Canonical (53, 54) |
| Wnt7a | Increased (49, 55) | Oncogene | No data in CRC |
| Tumor suppressor | Canonical (56) | ||
| Wnt7b | No data in CRC | ||
| Wnt8a | No data in CRC | ||
| Wnt8b | No data in CRC | ||
| Wnt9a | Decreased (57) | Tumor suppressor | Canonical (58) |
| Wnt9b | No data in CRC | Oncogene (59) | No data in CRC |
| Wnt10a | Increased (60, 61) | Oncogene | Canonical (60, 61) |
| Decreased (62) | No data in CRC | ||
| Wnt10b | No data in CRC | Oncogene | Canonical (63) |
| Wnt11 | Increased (64) | Oncogene | Non-canonical (65) |
| Wnt16 | No data in CRC | Oncogene (66) | No data in CRC |