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. 2020 Aug 14;11:1912. doi: 10.3389/fmicb.2020.01912

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Copyright © 2020 Zhang, Goraya, Chen, Xu, Hong, Zhu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Exogenous expression of ZC3HAV1 enhances the expression of antiviral innate immunity and inflammation. (A) A549 cells overexpressing ZAPL, ZAPS, or empty vector were infected with WSN. Bar graph shows the relative abundance of p-IRF3 protein (normalized to that of IRF3) from three experiments by using ImageJ software in A549 cells with exogenous expression of ZAPL, ZAPS, and empty vector after the virus infection. (B,C) qRT-PCR was performed to detect the expression of IFN-β and MxA mRNA in A549 cells with exogenous expression of ZC3HAV1 and empty vector after the virus infection. Data are represented as mean ± SD. ^∗p < 0.05; ^∗∗p < 0.01. (D,E) qRT-PCR analysis determined that the expression of TNF and IL-6 mRNAs was enhanced in ZC3HAV1-expressing A549 cells in comparison to empty vector control. Data are represented as mean ± SD. ^∗p < 0.05; ^∗∗p < 0.01.