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. 2020 Aug 14;7:483. doi: 10.3389/fvets.2020.00483

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Copyright © 2020 Driancourt and Briggs.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic presentation of the mechanisms involved in the prevention of reproductive function following the desensitization of the pituitary gland to GnRH. Thick arrows demonstrate stimulatory effects, while thin arrows document negative feed-back effects. For clarity of the graph, paracrine, and autocrine regulations within the testis have been omitted. Early effects of desensitization are pictured by . Events occurring later in the cascade of inhibitory effects are shown by and final ones by . Effects of GnRH desensitization on FSH concentrations in dogs are unknown, as there is no FSH assay validated for dog plasma and therefore no data.

Inline graphic — Schematic presentation of the mechanisms involved in the prevention of reproductive function following the desensitization of the pituitary gland to GnRH. Thick arrows demonstrate stimulatory effects, while thin arrows document negative feed-back effects. For clarity of the graph, paracrine, and autocrine regulations within the testis have been omitted. Early effects of desensitization are pictured by . Events occurring later in the cascade of inhibitory effects are shown by and final ones by . Effects of GnRH desensitization on FSH concentrations in dogs are unknown, as there is no FSH assay validated for dog plasma and therefore no data.