Table 1.
Amino acids 1, 6, and 10 are the ones modified to generates GnRH agonists used in dogs. |
Native GnRH: pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly. |
Deslorelin acetate: H-Pyr-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt.CH3CO2H. |
Azagly-nafarelin: H-Pyr-His-Trp-Ser-Tyr-D-2Nal-Leu-Arg-Pro-NHNHCONH2. |