Table 1.
Summary of the current available monoclonal antibodies raised against HLA-G isoforms.
| Designation | Specificity | Immunogen | References |
|---|---|---|---|
| MEM-G/1 | Denaturated heavy chain (α1 domain?) | Denaturated HLA-G1 heavy chain | (1–3) |
| MEM-G/2 | Denaturated heavy chain (α1 domain?) | Denaturated HLA-G1 heavy chain | (4) |
| MEM-G/4 | Denaturated heavy chain of HLA-G1, HLA-G2 and HLA-G5 | Denaturated HLA-G1 heavy chain | (5) |
| MEM-G/9 | Conformational HLA-G1/HLA-G5 isoforms associated with β2m | HLA-G recombinant protein refolded in presence of β2m and peptide | (5, 6) |
| G233 | Conformational HLA-G1/HLA-G5 isoforms associated with β2m | Murine cells transfected with HLA-G1/β2m associated isoform | (7–9) |
| 4H84 | Denaturated heavy chain (α1 domain) of HLA-G1 to HLA-G7 isoforms | Peptide encompassing the amino acids 61-83 of HLA-G α1 domain | (4, 5, 10, 11) |
| 5A6G7 | Soluble isoforms HLA-G5 and HLA-G6 | Peptide derived from intron 4 (SKEGDGGIMSVRESRSLSEDL) coupled with ovalbumin | (3, 12, 13) |
| 2A12 | Soluble isoforms HLA-G5 and HLA-G6 | Peptide derived from intron 4 (SKEGDGGIMSVRESRSLSEDL) coupled with ovalbumin | (14, 15) |
| 87G | Conformational HLA-G1/HLA-G5 isoforms associated with β2m and reported as blocking antibody | Murine cells transfected with HLA-G1/β2m associated isoform | (10, 16, 17) |
| HGY | Denaturated heavy chain (α1 domain?) | HLA-G purified proteins from placenta of pregnant women | (18, 19) |