Table 1.
Characteristics of participants (n = 130).
| Variables | Mean ± SD or No. (%) |
|---|---|
| Demographic variables | |
| Age at first MRI (years) | 74.1 ± 4.7 |
| Female | 61 (47%) |
| Level of Education | |
| No schooling | 42 (32%) |
| Low level | 44 (34%) |
| High level | 45 (34%) |
| APOE ε4 allele positive1 | 27 (21%) |
| Clinical variables of the last follow-up | |
| BMI (kg/m2) | 26.4 ± 3.8 |
| Hypertension3 | 55 (42%) |
| Diabetes2 | 18 (14%) |
| Cognitive variables of the last follow-up | |
| MMSE score4 | 26.7 ± 2.8 |
| FCSRT free recall score5 | 22.9 ± 7.8 |
| FCSRT total recall score5 | 42.8 ± 7.0 |
| Brain tissue changes between the first and the second MRI | |
| Gray matter atrophy (cm3) (min-max) | 16.79 ± 14.97 (−24.9–60.16) |
| Increase WMH lesion load (cm3) (min-max) | 3.30 ± 4.86 (−0.9–34.11) |
| Increase white matter MD (μm2/s) (min-max) | 53.26 ± 13.63 (29.23–98.68) |
Keys: SD, standard deviation; 1n = 106; 2n = 123; 3n = 123; 4n = 121; 5n = 109.