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. 2020 Aug 14;8:945. doi: 10.3389/fbioe.2020.00945

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Copyright © 2020 Arnesen, Kildegaard, Cernuda Pastor, Jayachandran, Kristensen and Borodina.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Overview of the MVA-pathway and terpenes produced by engineered Yarrowia lipolytica platform strains. Biosynthetic enzymes targeted for upregulation or downregulation are bolded and marked with upward or downward pointing arrows, respectively. ACL, ATP citrate lyase 1; SeACS, S. enterica acetyl-CoA synthetase; ACC, acetyl-CoA carboxylase; ERG10, acetyl-CoA acetyltransferase; ERG13, 3-hydroxy-3-methylglutaryl-CoA synthase; HMG, 3-hydroxy-3-methylglutaryl-CoA reductase; ERG12, mevalonate kinase; ERG8, phosphomevalonate kinase; ERG19, mevalonate diphosphate decarboxylase; IDI, isopentyl diphosphate isomerase; GPPS, geranyl diphosphate synthase; FPPS (ERG20), farnesyl diphosphate synthase; GGPPS, geranylgeranyl diphosphate synthase; SQS, squalene synthase; SQE, squalene epoxidase; ERG7, lanosterol synthase; PfLS, P. frutescens limonene synthase; AaBFS, A. annua β-farnesene synthase; CnVS, C. nootkatensis valencene synthase; XdCrtI, X. dendrorhous phytoene desaturase; XdCrtYB, X. dendrorhous bi-functional phytoene synthase/lycopene cyclase. Metabolic branchways are marked with colored arrows, monoterpene biosynthesis, blue. Sesquiterpene biosynthesis, turquoise. Triterpene biosynthesis, green. Diterpene and carotenoid biosynthesis, orange.