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. 2020 Aug 14;10:1316. doi: 10.3389/fonc.2020.01316

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Copyright © 2020 Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Blood biomarkers for AFP-negative hepatocellular carcinoma. ANHC, alpha-fetoprotein-negative hepatocellular carcinoma; cfDNA, circulating cell-free DNA; circRNAs, circular RNAs; DCP, des-gamma-carboxy prothrombin; AFP-L3, α-fetoprotein fraction L3; GP73, golgi protein 73; AKR1B10, aldo-keto reductase family 1 member B10; DKK1, dickkopf-1; MDK, midkine; Hsp90α, heat shock protein 90alpha; ANGPTL2, angiopoietin-like protein 2; PON1, paraoxonase 1; CAP2, cyclase-associated protein 2; CCT3, chaperonin containing TCP1 complex subunit 3; IQGAP3, IQ-motif-containing GTPase-activating protein-3; sAxl, soluble transforming receptor tyrosine kinase; OPN, osteopontin; MCM6, minichromosome maintenance complex component 6; CRP, c-reactive protein; TGM2, tissue transglutaminase 2; VASN, vasorin; HCCR-1, human cervical cancer oncogene 1; CYP17A1, the cytochrome P450, family 17, subfamily A, polypeptide 1; GS, glutamine synthetase; AGP, alpha-1 acid glycoprotein; THBS2, thrombospondin-2; IgG, immunoglobulin G; DHCR24 Ab, 3β-hydroxysterol Δ24-reductase antibody; ALP, alkaline phosphatase; ALT, alanine aminotransaminase; APTT, activated partial thromboplastin time; GGT, gamma-glutamyl transpeptidase.