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Observation of distinct polymorphs using TEM. Distinct polymorphs of HEWL formed at (A) pH 2, and (B) pH 6.3. Distinct polymorphs of HLZ formed at (C) pH 2, and (D) pH 6.3. Panels (E,F) show before (left) and after (right) sonication of HEWL mature fibrils to create seeds at pH 2 (E) and pH 6.3 (F).
