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. 2020 Aug 14;8:770. doi: 10.3389/fcell.2020.00770

FIGURE 4.

FIGURE 4

Loss of ANXA7 enhances receptivity. (A) Mice were pseudo-mated and the uteri collected at day 5.0 d.p.c. Arithmetic means ± SEM (n = AnxA7+/+; 6 and AnxA7–/ 5) of murine transcripts of Pr (Progesterone receptor), Hb-egf (Heparin binding -Egf), Bmp2 (Bone morphogenetic protein), Ihh (Indian hedgehog), Cox2 (Cyclooxygenase 2) and Prl8a2 (Decidual PRL-related protein) in AnxA7 knockout mice (AnxA7–/) and wild type littermates (AnxA7+/+). AnxA7–/– female mice crossed with wild type males and wild type females with AnxA7–/– males. Arithmetic means ± SEM of (B) number of implantation sites at 8.5 d.p.c. (n = 4) and (C) pups per litter (n = 5). (D) Human ANXA7 mRNA levels (GEO 65102) in RPL and Subfertile patients (n = 10). (E) Arithmetic means ± SEM (n = 10) of ANXA7 protein abundance in RPL and Subfertile patients patient samples. Demographic and clinical characteristics are presented in Supplementary Tables S1, S2. Student’s t-test was used to calculate statistical significance where *P < 0.05 and **P < 0.01.