Figure 2.

Effect of BRD4 silencing on TGF-β1–induced EMT marker production (E-cadherin, vimentin, and Snai1) production in human primary hNPDECs (A–C). Human primary hNPDECs were either transfected with siBRD4 or siCONT. Effect of BRD4 inhibitor JQ1 on TGF-β1 induction EMT marker production in human primary hNPDECs (D–F). E-cadherin, vimentin, and Snai1 mRNA expression was assessed by qRT-PCR. Fold change was calculated relative to siCONT–TGF-β1. All data are displayed as mean ± SD. The one-way ANOVA was used for statistical comparison. *P < 0.05, **P < 0.01 vs. controls.