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. 2020 Aug 14;11:556. doi: 10.3389/fendo.2020.00556

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Copyright © 2020 Ku and Cheng.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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ATF3 plays a vital role in breast cancer. ATF3 expression is increased by TGFβ. Furthermore, ATF3 upregulates the expression of some genes involved in tumor metastasis, including MMP13, fibronectin, TWIST1, Slug and Snail in the MCF10CA1a cells. Overexpression of miR-590-3p decreased cell proliferation and increased apoptosis via downregulation of the expression of ATF3 and Runx2 in MDA-MB231 cells. In addition, ATF-3 inhibits miR-590-3p expression to regulate miR-590/GOLPH3 pathway, and thus modulates proliferation of breast cancer cells. ATF3 was shown to be involved in radioresistance of breast cancer via PI3K/AKT signaling pathway. These observations show that ATF3 acts as an important regulator in breast cancer.