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. 2020 Aug 14;8:796. doi: 10.3389/fcell.2020.00796

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Copyright © 2020 Li, Tan, Wu, Ma, Bai, Xia, Wan and Liang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Resveratrol ameliorates ox-LDL-mediated endothelial dysfunction. (A) HUVECs were incubated with ox-LDL in the presence or absence of resveratrol. Cell viability was determined through MTT assay. (B,C) Immunofluorescence staining was used to observe the alterations of caspase-3 in endothelial cells under ox-LDL treatment. (D,E) RNA was collected from HUVECs after treatment with ox-LDL in the presence or absence of resveratrol. Then, transcription of cyclin D1 and cyclin (E) were measured to reflect endothelial cell proliferation. (F) Transwell assay was used to detect endothelial cell migratory response. The number of migrated endothelial cells was recorded. *p < 0.05.