FIGURE 5.
T cell-specific TTP conditional knockout mice are prone to DSS-induced colitis. Age- and body weight-matched CD4CreTTPf/f and control mice (8–12 weeks old) were administered with DSS in drinking water (2.5% wt/vol) for 5 days. Each group had five mice. Average body weight changes (A), bloody diarrhea (B), and survival (C) shown at indicated time points. On day 9, the lengths of colons of mice from treated groups were measured (D) and photographed (E). Sections of colons in each group were stained with hematoxylin and eosin (F). (G) Histological scores of colons collected from the above mice. Data are from four mice per group and represented as mean ± SD. *p < 0.05, **p < 0.01, and ***p < 0.001 between groups.