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Residual melanoma tumors upon MAPKi therapy exhibit L/L signature. The AMPK/HIF-1 signatures and TCA/glycolysis scores of BRAF-mutated tumor samples upon MAPKi treatment for the indicated time points. The RNA-Seq data are obtained from GEO with the series ID GSE75299. The red arrows denote the direction of the change of AMPK and HIF-1 activity of samples upon MAPKi treatment. The detailed information of the patients has been summarized in Supplementary Table 6.
