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. 2020 Aug 13;11:800. doi: 10.3389/fpsyt.2020.00800

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Copyright © 2020 Troyan and Levada

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diagnostic value of serum BDNF and IGF-1 for MDD diagnosis. (A) ROC curve for BDNF to diagnose MDD (p < 0.0001, AUC: 0.840; sensitivity; 81% and specificity: 73% for a cutoff of < 763.17 pg/ml). (B) ROC curve for IGF-1 to diagnose MDD (p < 0.0001, AUC: 0.824; sensitivity; 84% and specificity: 64% for a cutoff of > 178.00 ng/ml). (C) ROC curve the combination of BDNF and IGF-1 to diagnose MDD (p < 0.0001, AUC: 0.916). AUC, Area Under the ROC Curve; BDNF, Brain-Derived Neurotrophic Factor; IGF-1, Insulin-Like Growth Factor; MDD, major depressive disorder; ROC, receiver-operating characteristic.