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Progression of retinal degeneration. The major hallmarks of degeneration include RPE degradation and photoreceptor atrophy. In the case of wet AMD and some forms of RP, choroidal neovascularization may occur. In the last phase of degeneration, the large majority of the subretinal space undergoes drastic glial remodeling and scarring, as represented in phase III, which significantly obstructs cellular integration of stem cells.
