Table 3.
MCRs of CNVs differently distributed in meningiomas of different WHO grade, history of surgery, and tumor size.
| Cytoband | CNV | WHO grade | P | History of surgery | P | Tumor size | P | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| I | II | III | Primary | Recurrent | Small | Large | |||||
| 1p22.1 | 9.42 × 10−7** | 1.75 × 10−6** | |||||||||
| Loss | 40 | 16 | 4 | 42 | 18 | ||||||
| No change | 291 | 30 | 2 | 296 | 27 | ||||||
| 1p31.3 | 1.90 × 10−5** | 3.38 × 10−6** | 2.10 × 10−3* | ||||||||
| Loss | 50 | 19 | 4 | 52 | 21 | 26 | 47 | ||||
| No change | 244 | 24 | 2 | 249 | 21 | 151 | 119 | ||||
| Gain | 37 | 3 | 0 | 37 | 3 | 15 | 25 | ||||
| 1p34.3 | 9.30 × 10−5** | 3.50 × 10−7** | 9.65 × 10−6** | ||||||||
| Loss | 56 | 18 | 4 | 55 | 23 | 25 | 53 | ||||
| No change | 243 | 21 | 2 | 247 | 19 | 155 | 111 | ||||
| Gain | 32 | 7 | 0 | 36 | 3 | 12 | 27 | ||||
| 1q31.3 | 2.20 × 10−4** | ||||||||||
| No change | 300 | 35 | 3 | ||||||||
| Gain | 31 | 11 | 3 | ||||||||
| 1q42.12 | 7.64 × 10−6** | ||||||||||
| Loss | 36 | 8 | 1 | ||||||||
| No change | 264 | 27 | 1 | ||||||||
| Gain | 31 | 11 | 4 | ||||||||
| 2p24.1 | 1.88 × 10−4** | ||||||||||
| Loss | 19 | 2 | 3 | ||||||||
| No change | 294 | 39 | 3 | ||||||||
| Gain | 18 | 5 | 0 | ||||||||
| 4q13.3 | 4.01 × 10−7** | ||||||||||
| Loss | 22 | 4 | 4 | ||||||||
| No change | 309 | 42 | 2 | ||||||||
| 6q22.31 | 4.05 × 10−10** | 2.31 × 10−5** | |||||||||
| Loss | 15 | 8 | 4 | 17 | 10 | ||||||
| No change | 316 | 38 | 2 | 321 | 35 | ||||||
| 7p12.3 | 3.49 × 10−5** | ||||||||||
| Loss | 18 | 6 | 3 | ||||||||
| No change | 266 | 37 | 1 | ||||||||
| Gain | 47 | 3 | 2 | ||||||||
| 9p21.3 | 1.55 × 10−5** | 1.16 × 10−4** | |||||||||
| Loss | 9 | 6 | 2 | 10 | 7 | ||||||
| No change | 322 | 40 | 4 | 328 | 38 | ||||||
| 10p11.22 | 4.48 × 10−3* | ||||||||||
| Loss | 12 | 5 | 2 | ||||||||
| No change | 301 | 39 | 4 | ||||||||
| Gain | 18 | 2 | 0 | ||||||||
| 11p12 | 1.86 × 10−3* | 9.10 × 10−4** | |||||||||
| Loss | 12 | 7 | 1 | 13 | 7 | ||||||
| No change | 319 | 39 | 5 | 325 | 38 | ||||||
| 14q23.1 | 4.00 × 10−3* | 2.00 × 10−3* | |||||||||
| Loss | 39 | 13 | 2 | 41 | 13 | ||||||
| No change | 292 | 33 | 4 | 297 | 32 | ||||||
| 14q32.2 | 2.44 × 10−5** | ||||||||||
| Loss | 29 | 14 | 3 | ||||||||
| No change | 277 | 30 | 3 | ||||||||
| Gain | 25 | 2 | 0 | ||||||||
| 22q13.2 | 7.92 × 10−4** | ||||||||||
| Loss | 91 | 21 | 5 | ||||||||
| No change | 240 | 25 | 1 | ||||||||
MCRs, minimal common regions. P-values were calculated with chi-square tests. *P < 0.01; **P < 0.001. WHO grade was in accordance with 2016 WHO classification of meningiomas. Tumor size was dichotomized at median value of 4.30 cm. CNV, copy-number variation.