. Author manuscript; available in PMC: 2020 Aug 31.

Published in final edited form as: Mol Cancer Ther. 2011 Dec 27;11(2):370–382. doi: 10.1158/1535-7163.MCT-11-0458

Table 2.

Downregulated genes in tumors isolated from zebularine-treated mice

			Ratio of zebularine vs. control			Functional group by Gene Ontology

Gene ID	Gene symbol	Gene name	13 d^a	23 d^a	48 d^a	Cell cycle	Methylation and methylated genes	Metastasis	Positive regulation of cell proliferation	AKT/PI3K-signaling	Src-signaling	RAS-signaling

NM_009870	Cdk4	Cyclin-dependent kinase 4	0.66			+			+
BB209183	Cdc25C	Cell division cycle 25 homolog C (S. cerevisiae)	0.65			+			+
NM_023223.2	Cdc20	Cell division cycle 20 homolog (S. cerevisiae)	0.65			+			+
NM_008566.2	Mcm5	Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae)	0.59			+			+
BI658327.1	Mcm3	Minichromosome maintenance deficient 3 (S. cerevisiae)	0.67			+			+
NM_008569.2	Anapc1	Anaphase promoting complex subunit 1		0.55		+			+
BB828014	Trp53	Transformation related protein 53	0.54			+			+
BB183559	Hdac11	Histone deacetylase 11		0.59			+
BC004048	Wif1	Wnt inhibitory factor 1			0.31		+
BC019135	Mmp12	Matrix metalloproteinase 12		0.47				+
NM_008607	Mmp13	Matrix metalloproteinase 13			0.28			+
M94335	Akt1	Thymoma viral proto-oncogene 1	0.66						+	+
BB207248	Pik3cd	Phosphatidylinositol 3-kinase catalytic delta polypeptide		0.44							+
U52193	Pik3c2a	Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide		0.66							+
NM_007615	Catns	Catenin src	0.54					+			+
AK020374	Tnfrsf11a	Tumor necrosis factor receptor superfamily, member 11a	0.63									+
NM_013869	Tnfrsf19	Tumor necrosis factor receptor superfamily, member 19		0.66								+
NM_013832	Rasal1	RAS protein activator like 1 (GAP1 like)	0.61									+

Days of zebularine treatment.