Table 2.
Ratio of zebularine vs. control | Functional group by Gene Ontology | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gene ID | Gene symbol | Gene name | 13 da | 23 da | 48 da | Cell cycle | Methylation and methylated genes | Metastasis | Positive regulation of cell proliferation | AKT/PI3K-signaling | Src-signaling | RAS-signaling |
NM_009870 | Cdk4 | Cyclin-dependent kinase 4 | 0.66 | + | + | |||||||
BB209183 | Cdc25C | Cell division cycle 25 homolog C (S. cerevisiae) | 0.65 | + | + | |||||||
NM_023223.2 | Cdc20 | Cell division cycle 20 homolog (S. cerevisiae) | 0.65 | + | + | |||||||
NM_008566.2 | Mcm5 | Minichromosome maintenance deficient 5, cell division cycle 46 (S. cerevisiae) | 0.59 | + | + | |||||||
BI658327.1 | Mcm3 | Minichromosome maintenance deficient 3 (S. cerevisiae) | 0.67 | + | + | |||||||
NM_008569.2 | Anapc1 | Anaphase promoting complex subunit 1 | 0.55 | + | + | |||||||
BB828014 | Trp53 | Transformation related protein 53 | 0.54 | + | + | |||||||
BB183559 | Hdac11 | Histone deacetylase 11 | 0.59 | + | ||||||||
BC004048 | Wif1 | Wnt inhibitory factor 1 | 0.31 | + | ||||||||
BC019135 | Mmp12 | Matrix metalloproteinase 12 | 0.47 | + | ||||||||
NM_008607 | Mmp13 | Matrix metalloproteinase 13 | 0.28 | + | ||||||||
M94335 | Akt1 | Thymoma viral proto-oncogene 1 | 0.66 | + | + | |||||||
BB207248 | Pik3cd | Phosphatidylinositol 3-kinase catalytic delta polypeptide | 0.44 | + | ||||||||
U52193 | Pik3c2a | Phosphatidylinositol 3-kinase, C2 domain containing, alpha polypeptide | 0.66 | + | ||||||||
NM_007615 | Catns | Catenin src | 0.54 | + | + | |||||||
AK020374 | Tnfrsf11a | Tumor necrosis factor receptor superfamily, member 11a | 0.63 | + | ||||||||
NM_013869 | Tnfrsf19 | Tumor necrosis factor receptor superfamily, member 19 | 0.66 | + | ||||||||
NM_013832 | Rasal1 | RAS protein activator like 1 (GAP1 like) | 0.61 | + |
Days of zebularine treatment.