Fig. 2.

Dasatinib suppresses the secretion of IL-4 and TNF-α from antigen-stimulated MCs. IgE-primed RBL-2H3 cells were pre-treated with dasatinib or PP2 as indicated for 3 h before the addition of 50 ng/ml antigen. The amount of (A) IL-4 and (B) TNF-α were measured using by BDTM ELISA Kit as described in the section for “Materials and Methods”. The values represent the mean ± SEM from three independent experiments. Significant differences with antigen only are indicated, *p<0.01.