Table 1.
Characteristics of Infant Rhesus Macaques in the Study
| Identifier | Sex | MHC Class I Alleles | BCG Vaccinated | Age at SIV Positivity, wk | SIV TCID50 Resulting in Positivity/No. of Challenges | Peak Viral Load | Viral Load at Necropsy |
|---|---|---|---|---|---|---|---|
| A16079-ZZ | F | A1*004, A1*023, B*001, B*012 | No | 12 | 20 000/8 | 2.43E+08 | 2.43E+08 |
| A16080-AA | F | A1*002, B*015 | No | 10 | 12 000/6 | 5.05E+07 | 6.03E+06 |
| A16081-AB | F | A1*002, A1*006, B*012, B*024 | No | 15 | IV | 3.91E+08 | 3.91E+08 |
| A16082-ACa | F | … | No | 8 | 4000/4 | – | – |
| A16083-AD | M | A1*026, A1*002, B*001, B*055 | No | 11 | 15 000/7 | 1.06E+08 | 3.88E+05 |
| A17151-FT | F | … | No | 11 | 12 000/6 | 3.29E+07 | 2.14E+06 |
| A17152-FU | F | A1*004, A1*011, B*001, B*066 | No | 13 | 20 000/8 | 4.04E+08 | 4.04E+08 |
| A17153-FV | F | A1*023, A1*025, B*008, B*028 | No | 6 | 1000/2 | 2.68E+06 | 3.85E+05 |
| A17154-FW | F | A1*002, A1*004, B*001 | No | 10 | 12 000/6 | 4.90E+07 | 1.41E+07 |
| A16185-AT | F | A1*008, A1*032, B*012, B*068 | Yes | 10 | 12 000/6 | 1.07E+07 | 6.18E+06 |
| A16186-AUb | F | … | Yes | … | … | … | … |
| A16187-AV | M | A1*002, A1*001, B*015, B*002 | Yes | 8 | 4000/4 | 7.29E+07 | 7.29E+07 |
| A16188-AW | M | A1*004, B*012 | Yes | 15 | IV | 2.64E+08 | 2.55E+08 |
| A16189-AX | M | A1*012, A1*025, B*008 | Yes | 15 | IV | 2.82E+07 | 5.95E+05 |
| A17097-FA | F | A1*008, A1*011, B*001, B*008 | Yes | 10 | 12 000/6 | 5.74E+07 | 2.23E+06 |
| A17098-FB | M | A1*008, A1*023, B*012, B*015 | Yes | 13 | 20 000/8 | 1.74E+08 | 1.51E+08 |
| A17099-FC | F | A1*011, A1*023, B*012, B*024 | Yes | 10 | 12 000/6 | 3.29E+08 | 1.22E+08 |
| A17100-FD | M | A1*001, A1*023, B*002, B*028 | Yes | 13 | 20 000/8 | 1.09E+06 | 2.63E+06 |
Abbreviations: MHC, major histocompatibility complex; SIV, simian immunodeficiency virus; TCID50, median tissue culture infectious dose.
aInfant died prematurely 1 week after SIV challenge.
bInfant died prematurely 6 weeks after BCG vaccination and remained uninfected.