Table 2.
Univariate and multivariate Cox regression analysis for OS of patients in study cohort (n = 118)
| Variables | OS | ||
|---|---|---|---|
| HR | 95% CI | P value | |
| Univariate analysis | |||
| Age (≤ 50 years vs. > 50 years) | 0.774 | 0.418–1.490 | 0.588 |
| Gender (male vs. female) | 1.265 | 0.891–1.608 | 0.346 |
| Location (distal vs. middle + proximal) | 0.910 | 0.408–1.469 | 0.577 |
| Tumor size (> 5 cm vs. ≤ 5 cm) | 1.266 | 0.846–1.794 | 0.706 |
| Histologic differentiation (poorly + undifferentiated vs. well + moderately) | 1.640 | 0.848–2.426 | 0.178 |
| Invasion depth (T3 + T4 vs. T1 + T2) | 2.118 | 1.146–3.312 | 0.014 |
| TNM stage (III + IV vs. I + II) | 3.098 | 1.661–4.849 | 0.007 |
| Lymphatic metastasis (yes vs. no) | 1.211 | 0.594–1.459 | 0.057 |
| Distant metastasis (yes vs. no) | 1.298 | 0.792–1.899 | 0.030 |
| Expression of MIR99AHG (high vs. low) | 1.473 | 1.287–2.054 | 0.001 |
| Multivariate analysis | |||
| TNM stage (III + IV vs. I + II) | 2.699 | 1.401–4.984 | 0.006 |
| Invasion depth (T3 + T4 vs. T1 + T2) | 1.121 | 0.504–1.683 | 0.134 |
| Lymphatic metastasis (yes vs. no) | 1.073 | 0.691–1.662 | 0.455 |
| Distant metastasis (yes vs. no) | 0.998 | 0.701–1.492 | 0.074 |
| Expression of RP11-66B24.7 (high vs. low) | 2.851 | 1.044–4.630 | 0.035 |