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. 2020 Aug 27;18:118. doi: 10.1186/s12951-020-00680-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — In vitro sensitivity image of αHER2/PEG-NPs. MCF7/HER2 (HER2⁺⁺) cancer cells incubated with HER2 targeted-contrast agent with serial dilution concentrations. a αHER2/Lipo-DiR, αDNS/Lipo-DiR and Lipo-DiR were added to cells. Fluorescence images were obtained by the IVIS spectrum system. b Calculations of average radiant efficiency of (a). c αHER2/SPIO, αDNS/SPIO and SPIO were added to cells. MR imaging was performed with a 7.0 T MR imaging scanner. d The result from (c) was calculated by [treated SI-untreated SI]/untreated SI*100. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 (unpaired t test)