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. 2020 Aug 27;22:199. doi: 10.1186/s13075-020-02295-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — Allodynia is induced during SCW synovitis, but not different between WT and S100A9^−/−. Injection of saline did not induce changes in the pain threshold, but injection of SCW lowered the threshold significantly at day 1 (a). Although the threshold recovered partly at day 7, it was still significantly different from baseline. Allodynia in S100a9^−/− mice did not differ from WT and showed a highly similar pattern, indicating that S100A8/9 is not involved in sensitization. Significance was tested using a two-way ANOVA at n = 8 per group. A Tukey post hoc test was performed to identify significantly different means (*p < 0.05; **p < 0.01; ***p < 0.001)