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. 2020 Aug 27;22:199. doi: 10.1186/s13075-020-02295-9

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Of a panel of activation markers, ATF3, NAV1.7, and GAP43 are differentially expressed in DRG of arthritis WT versus S100A9^−/− mice. Three neuronal activation markers showed a significant increase in WT mice after SCW injection: NAV1.7 (a), ATF3 (b), and GAP43(c). These differences were found only 1 day after the injection of SCW. In S100a9^−/− mice, no increase in these markers were found, for ATF3 even a small decrease. At day 7, protein level NAV1.7 also seemed lower in S100a9^−/− compared to saline-injected mice, whereas in WT mice, the expression seemed increased (d; magnification × 200). This was quantified, and protein expression was lower at day 7 in S100a9^−/− mice, compared to WT (e). Significance was tested using a two-way ANOVA at n = 5 per group. A Tukey post hoc test was performed to identify significantly different means (*p < 0.05; **p < 0.01; ***p < 0.001)