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. 2020 Aug 27;51:107. doi: 10.1186/s13567-020-00829-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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NLRP3 played a role in T. spiralis -triggered immune response in vivo. WT and NLRP3^−/− mice were injected intraperitoneally (i.p.) with phosphate-buffered saline (PBS) or MLES (100 μg) twice at 7 days intervals. Spleen cells were isolated 7 days after second injection. A IFN-γ, IL-4, IL-10 and TGF-β production was measured by ELISA. B Treg populations induced by MLES were measured. CD4⁺CD25⁺Foxp3⁺ T cells were determined by flow cytometry. The data represent the means ± standard deviations (SD) of each group (n = 6) of the results from three individual experiments *p < 0.05, **p < 0.01, and ***p < 0.001 as indicated by the line (one-way ANOVA with Tukey’s post-test). These figures are representative of three independent experiments.