Table 1.
Commonly altered proteinsa in 3D neuro-spheroids derived from AD patients relative to those from control subjects.
| Accession | Description | Ratio | Coverage | Unique peptides | MW (kDa) |
|---|---|---|---|---|---|
| P21796 | Voltage-dependent anion-selective channel protein 1 (VDAC1) | 1.74 | 13 | 2 | 30.8 |
| P07196 | Neurofilament light polypeptide (NEFL) | 1.65 | 17 | 7 | 61.5 |
| P59768 | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 (GNG2) | 1.64 | 32 | 2 | 7.8 |
| P17677 | Neuromodulin (GAP43) | 1.58 | 72 | 14 | 24.8 |
| O43602 | Neuronal migration protein doublecortin (DCX) | 1.49 | 29 | 8 | 49.3 |
| P80723 | Brain acid soluble protein 1 (BASP1) | 1.46 | 82 | 15 | 22.7 |
| P05141 | ADP/ATP translocase 2 (SLC25A5) | 1.46 | 11 | 2 | 32.8 |
| P06576 | ATP synthase subunit beta, mitochondrial (ATP5B) | 1.38 | 32 | 12 | 56.5 |
| P09211 | Glutathione S-transferase P (GSTP1) | 0.84 | 43 | 6 | 23.3 |
| P18621 | 60S ribosomal protein L17 (RPL17) | 0.84 | 23 | 3 | 21.4 |
| P15880 | 40S ribosomal protein S2 (RPS2) | 0.82 | 20 | 5 | 31.3 |
| Q15121 | Astrocytic phosphoprotein PEA-15 (PEA15) | 0.82 | 45 | 5 | 15.0 |
| O00299 | Chloride intracellular channel protein 1 (CLIC1) | 0.81 | 41 | 8 | 26.9 |
| P07602 | Prosaposin (PSAP) | 0.81 | 26 | 12 | 58.1 |
| P06396 | Gelsolin (GSN) | 0.80 | 10 | 7 | 85.6 |
| P21333 | Filamin-A (FLNA) | 0.80 | 12 | 21 | 280.6 |
| Q96DG6 | Carboxymethylenebutenolidase homolog (CMBL) | 0.80 | 20 | 4 | 28.0 |
| P07355 | Annexin A2 (ANXA2) | 0.79 | 15 | 4 | 38.6 |
| P48681 | Nestin (NES) | 0.79 | 40 | 49 | 177.3 |
| P53985 | Monocarboxylate transporter 1 (SLC16A1) | 0.77 | 7 | 2 | 53.9 |
| P08670 | Vimentin (VIM) | 0.76 | 66 | 31 | 53.6 |
a
The proteins in the table are differentially regulated 3D proteins in at least 2 out of 5 AD patients when comparing each AD relative to the average of 5 controls.