Table 2.

Up- and down-regulated elements from AD patient-derived 3D neuron-spheroids.

Regulation	Category	Terms	p-Value
UP	BP	Cellular response to glucagon stimulus	≤ 0.028
	MF	Transmembrane transporter activity	≤ 0.017
		Protein binding	≤ 0.020
	CC	Mitochondrion	≤ 0.026
		Myelin sheath	≤ 0.001
DOWN	BP	Glutathione metabolic process	≤ 0.043
		Nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	≤ 0.003
		rRNA processing	≤ 0.011
		SRP-dependent cotranslational protein targeting to membrane	≤ 0.002
		translation	≤ 0.016
		Translational initiation	≤ 0.005
	MF	Cadherin binding involved in cell-cell adhesion	≤ 0.001
		mRNA binding	≤ 0.044
		poly(A) RNA binding	≤ 0.009
		Structural constituent of ribosome	≤ 0.012
	CC	Cell–cell junction	≤ 0.001
		Cytosolic large ribosomal subunit	≤ 0.047
		Cytosolic small ribosomal subunit	≤ 0.012
		Small ribosomal subunit	≤ 0.027

BP-Biological process, MF-Molecular function, CC-Cellular component.

Note: The table doesn’t include the general cellular components, such as cytoplasm, cytosol, extraocular exosome, and membrane.