Table 3.
The main KEGG pathways in up- and down-regulated 3D proteins of each AD analyzed by DAVID.
| Regulation | AD case | KEGG pathways | p-Value |
|---|---|---|---|
| UP | AD1 | Bile secretion | 3.00E-02 |
| UP | AD2 | Gap junction | 2.80E-08 |
| Pathogenic Escherichia coli infection | 3.80E-07 | ||
| Phagosome | 2.20E-04 | ||
| GABAergic synapse | 1.40E-03 | ||
| Dopaminergic synapse | 6.10E-03 | ||
| Glycolysis/gluconeogenesis | 6.70E-03 | ||
| DOWN | Ribosome | 1.30E-02 | |
| UP | AD3 | Parkinson’s disease | 1.80E-09 |
| Huntington’s disease | 8.20E-07 | ||
| Oxidative phosphorylation | 9.50E-03 | ||
| cGMP-PKG signaling pathway | 1.50E-02 | ||
| Alzheimer’s disease | 1.50E-02 | ||
| DOWN | AD4 | Ribosome | 9.60E-07 |
| Protein processing in endoplasmic reticulum | 2.40E-04 | ||
| RNA transport | 4.00E-03 | ||
| DOWN | AD5 | Ribosome | 7.50E-06 |