Table 1.
Significantly up- and downregulated human plasma proteins from AD patients compared to control subjects
| Accession | Description | Score Sequest HT | Coverage | # Unique Peptides | MW [kDa] | Ratio |
|---|---|---|---|---|---|---|
| P06727 | Apolipoprotein A-IV (APOA4) | 1764 | 82 | 31 | 45.4 | 0.74 |
| P02656 | Apolipoprotein C-III (APOC3) | 304 | 56 | 5 | 10.8 | 0.80 |
| P43652 | Afamin (AFM) | 1748 | 51 | 32 | 69 | 0.80 |
| P01023 | Alpha-2-macroglobulin (A2M) | 31728 | 73 | 74 | 163.2 | 0.82 |
| P02655 | Apolipoprotein C-II (APOC2) | 670 | 52 | 5 | 11.3 | 0.82 |
| P02787 | Serotransferrin (TF) | 21279 | 77 | 65 | 77 | 0.83 |
| P02749 | Beta-2-glycoprotein 1 (APOH) | 1180 | 65 | 15 | 38.3 | 0.83 |
| P02765 | Alpha-2-HS-glycoprotein (AHSG) | 2827 | 53 | 14 | 39.3 | 0.84 |
| Q96PD5 | N-acetylmuramoyl-L-alanine amidase (PGLYRP2) | 961 | 47 | 15 | 62.2 | 0.85 |
| Q96KN2 | Beta-Ala-His dipeptidase (CNDP1) | 266 | 34 | 14 | 56.7 | 0.86 |
| P51884 | Lumican (LUM) | 877 | 41 | 12 | 38.4 | 0.86 |
| P05452 | Tetranectin (CLEC3B) | 180 | 45 | 7 | 22.5 | 0.87 |
| O95445 | Apolipoprotein M (APOM) | 300 | 49 | 7 | 21.2 | 0.87 |
| P02647 | Apolipoprotein A-I (APOA1) | 6515 | 90 | 46 | 30.8 | 0.88 |
| P49908 | Selenoprotein P (SEPP1) | 65 | 20 | 7 | 43.2 | 0.89 |
| P29622 | Kallistatin (SERPINA4) | 705 | 42 | 15 | 48.5 | 0.89 |
| P05154 | Plasma serine protease inhibitor (SERPINA5) | 156 | 19 | 8 | 45.6 | 0.89 |
| P04196 | Histidine-rich glycoprotein (HRG) | 1345 | 38 | 17 | 59.5 | 0.90 |
| P00748 | Coagulation factor XII (F12) | 590 | 37 | 20 | 67.7 | 0.90 |
| P00488 | Coagulation factor XIII A chain (F13A1) | 251 | 21 | 13 | 83.2 | 0.90 |
| P80108 | Phosphatidylinositol-glycan-specific phospholipase D (GPLD) | 312 | 25 | 15 | 92.3 | 0.90 |
| P36955 | Pigment epithelium-derived factor (SERPINF1) | 1246 | 48 | 16 | 46.3 | 0.90 |
| Q6UXB8 | Peptidase inhibitor 16 (PI16) | 42 | 8 | 4 | 49.4 | 0.90 |
| Q04756 | Hepatocyte growth factor activator (HGFAC) | 85 | 20 | 11 | 70.6 | 0.91 |
| P43251 | Biotinidase OS = Homo sapiens (BTD) | 168 | 16 | 7 | 61.1 | 0.91 |
| O75882 | Attractin (ATRN) | 459 | 16 | 23 | 158.4 | 0.93 |
| O75636 | Ficolin-3 (FCN3) | 340 | 41 | 11 | 32.9 | 0.93 |
| P07360 | Complement component C8 gamma chain (C8G) | 288 | 53 | 8 | 22.3 | 0.95 |
| P02743 | Serum amyloid P-component (APCS) | 274 | 33 | 8 | 25.4 | 1.09 |
| P0C0L4 | Complement C4-A (C4A) | 11032 | 66 | 5 | 192.7 | 1.12 |
| P02748 | Complement component C9 (C9) | 1232 | 44 | 19 | 63.1 | 1.12 |
| P35542 | Serum amyloid A-4 protein (SAA4) | 149 | 28 | 4 | 14.7 | 1.14 |
| P61626 | Lysozyme C (LYZ) | 19 | 16 | 3 | 16.5 | 1.17 |
| P02750 | Leucine-rich alpha-2-glycoprotein (LRG1) | 1069 | 46 | 11 | 38.2 | 1.22 |
| P00738 | Haptoglobin (HP) | 12490 | 76 | 21 | 45.2 | 1.23 |
| P01011 | Alpha-1-antichymotrypsin (SERPINA3) | 7219 | 55 | 22 | 47.6 | 1.27 |
| P11226 | Mannose-binding protein C (MBL2) | 23 | 13 | 3 | 26.1 | 1.30 |
| P02763 | Alpha-1-acid glycoprotein 1 (ORM1) | 3668 | 56 | 8 | 23.5 | 1.31 |
| Q02985 | Complement factor H-related protein 3 (CFHR3) | 79 | 9 | 2 | 37.3 | 1.35 |
| P0DJI9 | Serum amyloid A-2 protein (SAA2) | 542 | 60 | 3 | 13.5 | 2.12 |
| P02741 | C-reactive protein (CRP) | 156 | 25 | 6 | 25 | 2.43 |
| P0DJI8 | Serum amyloid A-1 (SAA1) | 705 | 68 | 5 | 13.5 | 2.52 |
Up- and downregulated plasma proteins in AD group (n = 18) relative to the control group (n = 18) with p < 0.05, two-tailed Student’s T test from two independent studies.