Table 2.
Univariate and Multivariable Analysis of Risk Factors for OS
| Parameters | Univariate Analysis | Multivariable Analysis | ||
|---|---|---|---|---|
| HR (95% CI) | P value | HR (95% CI) | P value | |
| Age (year) | 1.143 (0.716–1.824) | 0.577 | … | … |
| <65 | ||||
| ≥65 | ||||
| Sex | 0.941 (0.561–1.579) | 0.819 | … | … |
| Male | ||||
| Female | ||||
| Comorbid disease | 1.989 (1.347–2.935) | 0.001* | 1.840 (1.237–2.735) | 0.003* |
| No | ||||
| Yes | ||||
|
Etiology HBV |
ref | … | … | … |
| HCV | 1.201 (0.486–2.967) | 0.691 | … | … |
| Alcohol-induced | 1.691 (0.643–4.447) | 0.287 | … | … |
| Pathological differentiation | 1.523 (0.682–1.921) | 0.372 | … | … |
| Well/moderately | ||||
| Poorly | ||||
| Cirrhosis | 0.927 (0.431–1.994) | … | … | |
| No | ||||
| Yes | ||||
| Recurrence time (years) | 0.407 (0.272–0.607) | 0.001* | 0.460 (0.301–0.704) | <0.001* |
| <1 | ||||
| ≥1 | ||||
| Tumor size (cm) | 0.940 (0.624–1.417) | 0.768 | … | … |
| <3 | ||||
| 3–5 | ||||
| Tumor number | 0.767 (0.534–1.101) | 0.150 | … | … |
| 1 | ||||
| 2–3 | ||||
| Adjacent to organ | ||||
| No | Ref | … | ||
| Major vessels | 1.623 (0.517–2.982) | 0.382 | … | … |
| Diaphragm | 1.787 (0.612–2.981) | 0.562 | … | … |
| Gastrointestinal tract | 1.112 (0.311–1.872) | 0.781 | … | … |
| CTP grade | 10.626 (2.487–45.410) | 0.032* | … | … |
| A | ||||
| B | ||||
| ALBI grade | 12.573 (6.737–23.466) | <0.001* | 11.525(5.661–23.463) | <0.001* |
| 1 | ||||
| 2–3 | ||||
| α-fetoprotein level (ng/mL) | 1.418 (0.966–2.082) | 0.074 | … | … |
| ≤20 | ||||
| >20 | ||||
Note: * shows statistically significant result.
Abbreviations: ALBI, albumin-bilirubin; CTP, Child-Turcotte-Pugh; BCLC, Barcelona Clinic Liver cancer; TACE, transarterial chemoembolization; RFA, radiofrequency ablation; MWA, microwave ablation.