Table 4.
The Association of the HTGW Phenotype with UACR in Different Subgroups of Age, Blood Glucose and Blood Pressure
| Variable | NWNT HTG EW HTGW | P-values | |||
|---|---|---|---|---|---|
| Reference | OR(95% CI) P value | OR(95% CI) P value | OR(95% CI) P value | For Interaction | |
| Age, year a | 0.127 | ||||
| <55 (n=15,704) | 1 | 1.260(0.974–1.629) 0.079 | 1.007(0.790–1.284) 0.954 | 1.407(1.094–1.809)* 0.008 | |
| 55–64 (n=15,264) | 1 | 1.197(0.970–1.476) 0.093 | 0.938(0.759–1.158) 0.552 | 1.338(1.061–1.686)* 0.014 | |
| ≥65 (n=9706) | 1 | 0.972(0.781–1.210) 0.800 | 1.208(0.927–1.574) 0.163 | 1.086(0.836–1.411) 0.536 | |
| Blood glucose, mmol/L b | 0.002 | ||||
| FBG<5.6 and PBG<7.8 (n=16,035) | 1 | 1.145(0.943–1.390) 0.173 | 1.038(0.846–1.273) 0.722 | 1.217 (0.992–1.492) 0.059 | |
| 5.6≤FBG<7.0 or 7.8≤PBG<11.1 (n=16,107) | 1 | 1.243(1.001–1.543)* 0.049 | 1.153(0.923–1.441) 0.209 | 1.425(1.124–1.808)* 0.004 | |
| FBG≥7.0 or PBG≥11.1 (n=8532) | 1 | 1.017(0.858–1.206) 0.845 | 1.193(0.988–1.440) 0.067 | 1.146(0.922–1.407) 0.193 | |
| BP, mmHg c | 0.234 | ||||
| SBP<120 and DBP<80 (n=13,190) | 1 | 1.236(0.896–1.705) 0.197 | 0.954(0.714–1.276) 0.751 | 1.299(0.960–1.756) 0.090 | |
| 120≤SBP<140 and/or 80≤DBP<90 (n=15,384) | 1 | 1.128(0.956–1.331) 0.152 | 1.153(0.960–1.385) 0.127 | 1.268(1.038–1.549)* 0.020 | |
| SBP≥140 or DBP≥90 (n=12,100) | 1 | 1.048(0.875–1.255) 0.613 | 1.097(0.890–1.352) 0.388 | 1.170(0.941–1.456) 0.158 | |
| eGFR, mL/min per 1.73m2 d eGFR≥90 (n=37,617) |
1 |
1.108(0.952–1.290) 0.186 |
1.079(0.932–1.249) 0.311 |
1.199(1.047–1.484)* 0.009 |
0.183 |
| 60≤eGFR<90 (n=2808) | 1 | 1.253(0.796–1.974) 0.330 | 1.242(0.831–1.858) 0.291 | 1.337(0.910–1.946) 0.139 | |
| eGFR<60 (249) | 1 | 0.988(0.617–1.583) 0.961 | 1.110(0.735–1.678) 0.619 | 1.131(0.759–1.685) 0.546 | |
| BMI, kg/m2 e BMI<18.5 (n=1117) |
1 |
1.305(0.961–1.772) 0.088 |
0.952(0.747–1.215) 0.695 |
1.247(0.965–1.610) 0.091 |
0.136 |
| 18.5≤BMI<24 (n=18,097) | 1 | 1.107(0.806–1.519) 0.530 | 1.007(0.783–1.296) 0.956 | 1.074(0.842–1.399) 0.598 | |
| 24≤BMI<28 (n=15,669) | 1 | 1.002(0.833–1.206) 0.981 | 1.170(0.948–1.444) 0.143 | 1.268(1.008–1.595)* 0.043 | |
| BMI≥28 (n=5791) | 1 | 1.019(0.779–1.335) 0.889 | 0.964(0.746–1.246) 0.779 | 1.086(0.787–1.499) 0.615 | |
Notes: *Significant data (P<0.05): aFor age subgroup: adjusted for sex, centres, ALT, AST, LDL-C, HDL-C, TC, PBG, PBG, SBP, DBP, eGFR, BMI, smoking habits, drinking habits, CVD status, hypertension history, diabetes history, use diabetes drugs and hypertension drugs status: bFor blood glucose subgroup: adjusted for age, sex, centres, ALT, AST, LDL-C, HDL-C, TC, SBP, DBP, eGFR, BMI, smoking habits, drinking habits, CVD status, hypertension history, use hypertension drugs status: cFor blood pressure subgroup: adjusted for age, sex, centres, ALT, AST, LDL-C, HDL-C, TC, FBG, PBG, eGFR, BMI, smoking habits, drinking habits, CVD status, diabetes history, use diabetes drugs status: dFor eGFR subgroup: adjusted for age, sex, centres, ALT, AST, LDL-C, HDL-C, TC, FBG, PBG, SBP, DBP, BMI, smoking habits, drinking habits, CVD status, hypertension history, diabetes history, use diabetes drugs and hypertension drugs status: eFor BMI subgroup: adjusted for age, sex, centres, ALT, AST, LDL-C, HDL-C, TC, FBG, PBG, eGFR, SBP, DBP, smoking habits, drinking habits, CVD status, hypertension history, diabetes history, use diabetes drugs and hypertension drugs status.
Abbreviations: NWNT, normal waist and normal triglyceride; HTG, normal waist with hypertriglyceridemia; EW, enlarged waist circumference; HTGW, hypertriglyceridemic waist; UACR, urinary albumin-creatinine ratio; FPG, fasting plasma glucose; PPG, postprandial plasma glucose; BP, blood pressure; SBP, systolic blood pressure; DBP, diastolic blood pressure.