Table 1.

Effects of antioxidants and selenium treatments on possible therapeutic targets in different experimental neurological disease models of rodents (TBI, traumatic brain injury; SCI, spinal cord injury).

Channel	Agent	Material	Value/Effect	Refs.
TRPA1	NAC	Mice	Ischemia and oxidative stress induced peripheral postischemic dysesthesia treatment	[24, 87]
TRPA1	Resveratrol	Rat DRG and HEK-293 cells	TRPA1 inhibition	[83]
TRPA1-TRPV1	NAC	Rats	Cigarette smoke induced superior laryngeal irritation treatment	[192]
TRPA1-TRPV1	17-β estradiol, tamoxifen and raloxifene	Rat DRG	Inhibition of peripheral pain, TRPA1 and TRPV1	[88]
TRPM3	Flavones	Rats	Inhibition of TRPM3 mediated thermal hyperalgesia	[193]
TRPV1	Hypericum perforatum extract	Rat DRG	SCI-induced pain and neuronal death reduction	[194]
TRPV1	NAC and GSH	Mice DRG	TRPV1 Inhibition	[72]
TRPV1	Selenium and NAC	Rat hippocampus	Treatment of TBI induced rats	[118]
TRPV1	Dexmedetomidine	Rat hippocampus and DRG	Neuroprotective effects on cerebral ischemia induced-oxidative stress	[195]
TRPV1	Vitamin C, E and NAC	Rats	Treatment of cortical neuronal death via TRPV1	[196]
TRPV1	Curcumin	Rats	Inhibits TRPV1 mediated pain hypersensitivity	[197]
TRPV1	Selenium	Rats	Inhibits memory impairments	[117]
TRPV1	Hypericum perforatum	Rats	Inhibiting SCI	[198]
TRPV1	Melatonin and selenium	Rat hippocampus and DRG	Neuroprotection in diabetic rats	[19]
TRPV1	Melatonin and selenium	MCF-7 cells	Inhibiting TRPV1 and enhanced chemotherapeutic action	[115, 116]
TRPV4	Trolox and MitoE	Rats	Oxidative stress-induced neuronal and astrocytic damage attenuated in hippocampal slices	[186]
TRPV4	Trolox	Rat hippocampal slices	Amyloid β induced neuronal and astrocytic damage attenuated	[143]