Table 1.
Publications on gene variants associated with opioid use disorder (OUD) as related to diversity of study cohort.
| Genes | Variants (SNPs and Haplotypes) | Publication Describing Association with Opioid Dependence | Publications that Consider Caucasians | Publications that Consider Chinese | Publications that Consider Hispanics | Publications that Consider African Ancestry |
|---|---|---|---|---|---|---|
| DRD2 | rs6275; rs6277; rs1076560; rs1799978; rs1800496; rs1801028 | Clarke, T.K. et al. [94]; Hou, Q.F. and Li, S.B. [95]; Vereczkei, A. et al. [96]; Lawford, B.R. et al. [98]. | Clarke, T.K. et al. [94]; Vereczkei, A. et al. [96]; Lawford, B.R. et al. [98]. | Hou, Q.F. and Li, S.B. [95]. | Clarke, T.K. et al. [94]. | |
| DRD3 | rs6280 rs9825563 rs2654754 rs9288993 rs1486009 |
Levran, O. et al. [99]; Kuo, S.C. et al. [100]. | Levran, O. et al. [99]. | Kuo, S.C. et al. [100]. | ||
| DRD4 | rs1800955 | Vereczkei, A. et al. [96]; Szilagyi, A. et al. [102]; Ho. A.M. et al. [103]; Lai, J.H. et al. [104]. | Vereczkei, A. et al. [96]; Szilagyi, A. et al. [102]. | Ho. A.M. et al. [103]; Lai, J.H. et al. [104]. | ||
| OPRM1 | rs1799971 rs1799972 |
Bond, C. et al. [115]; Crowley, J.J. et al. [120]; Szeto, C.Y. et al. [123]; Shi, J. et al. [124]; Hastie, B.A. et al. [118]. | Bond, C. et al. [115]; Crowley, J.J. et al. [120]; Hastie, B.A. et al. [118]. | Szeto, C.Y. et al. [123]; Shi, J. et al. [124]. | Bond, C. et al. [115]; Crowley, J.J. et al. [120]; Hastie, B.A. et al. [118]. | Bond, C. et al. [115]; Crowley, J.J. et al. [120]; Hastie, B.A. et al. [118]. |
| OPRD1 | rs1042114 rs678849 rs10753331 rs529520 rs581111 rs2234918 |
Zhang, H. et al. [129]; Levran, O. et al. [130]; Nelson, E.C. et al. [131]; Levran, O. et al. [132]; Crist, R.C. et al. [122]; Sharafshah, A. et al. [133]; Beer, B. et al. [134]. | Zhang, H. et al. [129]; Crist, R.C. et al. [122];Levran, O. et al. [130]; Nelson, E.C. et al. [131]; Beer, B. et al. [134]. | Levran, O. et al. [132]; Crist, R.C. et al. [122]. | ||
| KCNC1; KCNG2 |
rs60349741 rs62103177 |
Gelernter, J. et al. [146]. | Gelernter, J. et al. [146]. | Gelernter, J. et al. [146]. | ||
| OPRK1 | rs1051660 | Yuferov, V. et al. [135]; Jones, J.D. et al. [136]; Nagaya, D. et al. [137]; Zhang, H. et al. [129]; Albonaim, A. et al. [138]; Gerra, G. et al. [139]; Kumar, D. et al. [140]; Levran, O. et al. [130]. | Yuferov, V. et al. [135]; Jones, J.D. et al. [136]; Zhang, H. et al. [129]; Gerra, G. et al. [139]; Levran, O. et al. [130]. | Yuferov, V. et al. [135]; Jones, J.D. et al. [136]. | Yuferov, V. et al. [135]; Jones, J.D. et al. [136]. | |
| BDNF | rs6265; rs11030104; rs10767664; rs13306221; rs56164415; rs13306221; rs16917204; rs7127507; rs1967554; rs11030118; rs988748; rs2030324; rs11030119 | Jin, T. et al. [152]; Jia, W. et al. [153]; Su, H. et al. [155]; de Cid, R. et al. [156]. | Jin, T. et al. [152]; Jia, W. et al [153]; Su, H. et al. [155]. | |||
| NRXN3 | rs10144398 rs10151731 rs10083466 rs1424850 rs221497 rs221473 |
Panagopoulos, V.N. et al. [159]; Lachman, H.M. et al. [160]. | Panagopoulos, V.N. et al. [159]; Lachman, H.M. et al. [160]. | Lachman, H.M. et al. [160]. | Lachman, H.M. et al .[160]. | |
| COMT | rs4680 | Henker, R.A. et al. [162]; Vereczkei, A. et al. [96]; Li, T. et al. [163]; Rakvåg, T.T. et al. [164]. | Henker, R.A. et al. [162]. | Vereczkei, A. et al. [96]; Li, T. et al. [163]; Rakvåg, T.T. et al. [164]. | ||
| SLC6A4 | rs25531 rs1042173 |
Saiz, P.A. et al. [166]; Gerra, G. et al. [167]; Szilagyi, A. et al. [102]; Iamjan, S.A. et al. [154]. | Gerra, G. et al. [167]; Szilagyi, A. et al. [102]. | Saiz, P.A. et al. [166]; Iamjan, S.A. et al. [154]. |