Table 2.

Ligands of the group II mGlu cited in the text.

Ligands	Pharmacological Profile	Refs.
(2R,4R)-APDC	Broad spectrum group II mGlu agonist, also active at other mGlu receptors	[1, 103]
DGC-IV	Broad spectrum group II mGlu agonist	[1, 104]
NAAG	mGlu3 agonist	[123, 124]
LY354740	mGlu2/3 agonist	[13, 106, 107]
LY379268	mGlu2/3 agonist	[13, 106, 107]
LY341495	Broad spectrum group II mGlu antagonist	[110]
LY541850	Mixed ligand (mGlu2 agonist / mGlu3 antagonist)	[1]
LY566332	mGlu2 PAM	[99, 113]
LY2389575	mGlu3 NAM	[114]
BINA	mGlu2 PAM	[112]
ML 337	mGlu3 NAM	[116]
DN10	Nanobody, mGlu2 PAM, partial agonist at mGlu2	[17]
DN13	Nanobody, mGlu2 PAM	[17]