Fig. 5.

Loss of UBR5 results in reduction of tumor volume in NRGs mice. a A549 cells were infected with the lenti-viruses from multiple shRNA construct against UBR5. Twenty-four hours post infection, cells were harvested and 1.25 × 10⁵ cells were subcutaneously injected in mice flanks (L-NT shRNA & R-shRNA against UBR5). b Mice were euthanized 4 weeks after injection and tumor were measure. c Wilcoxon paired t-test were used to calculate the significance of difference between tumor volume