Table 3.
Evolutionary conservation pattern of amino acids with solvent accessibility in HLA-G1 by ConSurf server
| Isoform 1 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| conservation score | exposed or buried | prediction | conservation score | exposed or buried | prediction | conservation score | exposed or buried | prediction | conservation score | exposed or buried | prediction |
| M29 | L105 | C188 | D244 | ||||||||
| 1 (variable) | buried | - | 1 (variable) | buried | - | 9 (conserved) | buried | structural | 7 (conserved) | exposed | - |
| R30 | H117 | L196 | P259 | ||||||||
| 6 (average) | buried | - | 9 (conserved) | buried | structural | 9 (conserved) | buried | structural | 9 (conserved) | exposed | functional |
| P39 | D130 | R205 | Q266 | ||||||||
| 9 (conserved) | exposed | functional | 8 (conserved) | exposed | functional | 7 (conserved) | exposed | - | 9 (conserved) | exposed | functional |
| Y51 | Y142 | P209 | V285 | ||||||||
| 9 (conserved) | exposed | functional | 9 (conserved) | buried | structural | 9 (conserved) | buried | structural | 9 (conserved) | buried | structural |
| D53 | D143 | C227 | H287 | ||||||||
| 9 (conserved) | buried | structural | 9 (conserved) | exposed | functional | 9 (conserved) | buried | structural | 9 (conserved) | buried | structural |
| D54 | D153 | A229 | L290 | ||||||||
| 8 (conserved) | exposed | functional | 9 (conserved) | exposed | functional | 9 (conserved) | buried | structural | 9 (conserved) | buried | structural |
| Q96 | W157 | P234 | L294 | ||||||||
| 7 (conserved) | exposed | - | 9 (conserved) | buried | structural | 9 (conserved) | exposed | functional | 6 (average) | buried | - |
| L102 | T158 | I237 | W298 | ||||||||
| 9 (conserved) | buried | structural | 9 (conserved) | exposed | functional | 9 (conserved) | buried | structural | 8 (conserved) | exposed | functional |
Conservation score has a range of 1.0 to 9.0. Score 9 represents the most conserved and 1 represents the very variable amino acid. An amino acid, if is preserved and exposed, is a functional residue and if is preserved and buried, is a structural residue