Table 1.

Population and Characteristics of EVs

	Exosome	MV (MP)	AB
Size	30–200 nm	100–1000 nm	1000–3000 nm
Shape	Homogeneous	Variable	Variable
Origine	MBV fusion with the plasma membrane	Budding from the plasma membrane	Budding from the plasma membrane
Markers	Tetraspanins (CD9, CD63, CD81) Alix, TSG101, HSP70	Annexin V, Integrin, Selectin, CD40 ligand, metalloproteinase	Annexin V, DNA fragment Caspase 3, Histones
Isolation	Ultracentrifugation (100,000g)	Ultracentrifugation (10,000–100,000g)	Ultracentrifugation (6000–10,000g)
P-Act	Weak	Powerful	Powerful

Notes: Data from Nomura.11 All vesicles preparations are heterogeneous with different protocols allowing the enrichment of one type over another.

Abbreviations: MV, microvesicle; MP, microparticle; AB, apoptotic body; MBV, multivesicular body; TSG101, tumor susceptibility gene 101; HSP70, heat shock protein 70; P-Act, procoagulant activity.