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. 2020 Aug 21;14:3417–3427. doi: 10.2147/DDDT.S256813

Figure 4.

Figure 4

IncRNA XIST targeted miR-200a-3p to up-regulate NRP1 expression. (A) NRP1 expression in cancer tissues and adjacent tissues. The diagnostic AUC of NRP1 was > 0.8. (B) Compared with ARPE-19, NRP1 was significantly up-regulated in Y79. (C) NRP1 was significantly down-regulated in high/medium differentiation tissues than that in low differentiation tissues. (D) NRP1 expression after transfection with Y79. (E) Luciferase activity of Y79; (F) XIST was negatively correlated with miR-200a-3p (r= −0.8883, P<0.001). (G) MiR-200a-3p was negatively correlated with NRP1 (r= −0.9123, P<0.001). (H) XIST was positively correlated with NRP1 expression (r= 0.8760, P<0.001).

Note: aIndicates P<0.001.