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. 2020 Aug 21;13:8373–8382. doi: 10.2147/OTT.S248085

Figure 2.

Figure 2

ADAMTS8 knockdown promotes proliferation, migration, invasion and inhibits apoptosis of BC cells. (A) Expression of ADAMTS8 protein was examined with Western blotting in MDA-MB-231 cells stably transfected with psi-H1-ADAMTS8siRNA or psi-H1 plasmids. (B) CCK-8 assay showing that ADAMTS8 knockdown promotes proliferation of MDA-MB-231 cells. (C) Quantification of results from B. (D) Wound-healing assay showing that ADAMTS8 knockdown promotes migration of MDA-MB-231 cells. (E) Quantification of results from D. (F) Transwell assay showing that ADAMTS8 knockdown promotes invasion of MDA-MB-231 cells. (G, H) Quantification of results from F. (I) Flow cytometry showing that ADAMTS8 knockdown inhibits apoptosis of MDA-MB-231 cells. (J) Quantification of results from (I). *P < 0.05, **P < 0.01.

Abbreviations: ADAMTS8, a disintegrin and metallopeptidase with thrombospondin motif 8; BC, breast cancer; CCK-8, cell counting kit-8.