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. 2020 Aug 21;13:8373–8382. doi: 10.2147/OTT.S248085

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© 2020 Zhang et al.

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Overexpression of ADAMTS8 increases the chemotherapy sensitivity and attenuates β-catenin, MMP-7 and c-Myc protein levels in BC cell. (A) MDA-MB-453 cells stably transfected with pEZ-M90-ADAMTS8 or pEZ-M90 plasmids were treated with increasing concentrations of chemotherapy drug cisplatin, doxorubicin, or cyclophosphamide. CCK-8 assay analyzed cell survival. (B) Expression of β-catenin, MMP-7 and c-Myc protein was examined with Western blotting in MDA-MB-453 cells stably transfected with pEZ-M90-ADAMTS8 or pEZ-M90 plasmids. (C) Quantification of results from (B). *P < 0.05, **P < 0.01.

Abbreviations: ADAMTS8, a disintegrin and metallopeptidase with thrombospondin motif 8; MMP-7, matrix metalloproteinase-7; BC, breast cancer; CCK-8, cell counting kit-8.