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. 2020 Aug 24;13:8521–8532. doi: 10.2147/OTT.S256274

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© 2020 Sun et al.

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Verification of SCG-7901/5‑FU cells establishment. (A and B) The NHE1 expression in three different gastric cell lines. (C) Growth inhibition rate of three different gastric cell lines in response to 5-FU. (D) IC₅₀ value of the parental gastric cancer (SGC7901) and 5-fluorouracil resistant gastric cancer cell lines SGC7901/FU. (E) Growth inhibition rate of the parental gastric cancer (SGC7901) and 5-fluorouracil resistant gastric cancer cell lines SGC7901/FU in response to 5-FU. (F) Resistance Index of the parental gastric cancer line SGC7901 and its 5-fluorouracil resistant cell lines to 5-FU. (G and H) Drug resistance related proteins (GST-π and P-gp) were up-regulated in the 5-fluorouracil resistant gastric cancer cell SGC7901/FU contrast to the parental cell lines. *P<0.05, compared to the control group.