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. 2020 Aug 24;13:8521–8532. doi: 10.2147/OTT.S256274

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© 2020 Sun et al.

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NHE1 attenuate the cell apoptosis mediated by 5-FU (A). Relative mRNA expression of NHE1 in the GES-1 cell line, the parental gastric cancer (SGC7901), and 5-fluorouracil resistant gastric cancer cell lines SGC7901/FU. (B and C) The relative protein expression of NHE1 after plasmids transfection. (D) Cell apoptosis percentage of SGC7901 cell line. Blue represents Dapi stain, Red represents the apoptosis cells. (E) The concentration of caspase 3. (F and G) The expression of anti-apoptosis proteins (Bcl-xl and Bcl-2). Error bars denote SD. *P<0.05, compared to the control group. **P<0.01, compared to the control group.