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[Preprint]. 2021 Feb 19:2020.08.28.272880. Originally published 2020 Aug 28. [Version 2] doi: 10.1101/2020.08.28.272880

Figure 6. Comparative anti-SARS-CoV-2 activity of PF-00835231 and remdesivir in polarized human airway epithelial cultures (HAEC).

Figure 6.

To test for antiviral activity, drugs were added to the basolateral chamber, cultures infected with SARS-CoV-2 from the apical side, and apical washes collected in 12 h increments to determine viral titers by plaque assay. a, b. SARS-CoV-2 USA-WA1/2020 infectious titers from HAEC treated with incremental doses of remdesivir (a.) or PF-00835231 (b.). c. Representative top views of HAEC at 72 hpi; drug doses 0.3 μM. Blue, DAPI (nuclei); cyan, ZO-1 (tight junctions); red, SARS-CoV-2 N protein (infected).