Table 2.
Vascular Function in Systemic Arteries
| Non-Smoking Controls (n = 26) | Smoking Controls (n = 20) | COPD without PVD (n = 45) |
COPD with PVD (n = 15) |
|
|---|---|---|---|---|
| Flow-mediated dilation, % change from baseline diameter | 10.10 (6.15–14.30) | 6.60 (4.58–9.50) | 5.40 (3.13–7.30) a | 2.70 (0.78–4.70) ab |
| Flow-mediated dilation/Baseline brachial artery diameter, %/mm | 2.50 (1.48–3.82) | 1.34 (0.80–2.04) | 1.16 (0.49–1.65) a | 0.49 (0.18–1.02) ab |
| Augmentation index, % | 25.0 (19.3–35.3) | 33.0 (20.0–43.0) | 25.0 (17.3–30.0) | 27.0 (17.3–34.0) |
| Augmentation index 75, % | 23.5 (17.0–29.3) | 26.0 (20.0–40.0) | 27.0 (16.8–31.0) | 26.0 (19.5–31.8) |
| Pulse wave velocity, m/s | 8.3 (6.6–9.7) | 7.6 (6.6–8.9) | 9.8 (8.4–11.8) ab | 11.4 (10.4–13.2) abc |
Notes: Results are expressed as median (percentile 25-percentile 75). Non-adjusted comparisons: ap<0.05 compared with non-smokers; b p<0.05 compared with smokers; c p<0.05 compared with COPD without PVD.
Abbreviations: COPD, chronic obstructive pulmonary disease; PVD, pulmonary vascular disease.