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The proposed schematic representation for GAST in GC development and progression. The scheme indicated that GAST was the direct target gene of miR-30a-3p in GC cell lines and tissues, suggested that miR-30a-3p was the promising tumor suppressor gene in GC. Furthermore, elevated GAST expression promoted cell proliferation, migration and invasion through STAT3 phosphorylation and up-transactivation of MMP11 expression.
