Figure 1.

Schematic illustration of the preparing electrospun nanofibers, crosslinking of the nanofibers, the mode of action of crosslinking, and the applying of nanofibers as a wound dressing.

Notes: Heat treatment crosslinked illustration only shows parts of hydrogen bonding. Functional groups that can form hydrogen bonding in nanofibers are polyether groups in PEO, amine (NH₂) and terminal carboxylates (–COOH) in CET’s protein, and amine (NH₂) and hydroxyl (OH) in chitosan.

Abbreviations: PEO, poly(ethylene oxide); CET’s protein, Colocasia esculenta tuber protein; ECM, extracellular matrix.