Table 2.

Synthetic Quorum Sensing Inhibitors, Their Targets, and Effects on the P. aeruginosa QS system

Quorum Sensing Inhibitor Compounds	Target	Quorum Sensing Efficacy	Ref.
N-decanoyl-L-homoserine benzyl ester	AHL-mediated	Protease, elastase, rhamnolipid secretion and motility phenotypes	[164]
Synthetic triazole containing analogs of AHL	LuxR-LasR analogs	LasR receptor	[165]
N-(indole-3-butanoyl)-L-HSL	AHL-mediated	Pathogenic factors production, production of biofilm	[166]
2-heptyl-6-nitro-4-oxo-1,4-dihydroquinoline-3-	PqsR analog	Virulence factor production	[115]
N-(heptyl-sulfanyl acetyl)-L-HSL (HepS-AHL)	AHL-mediated	transcriptional regulator - LasR	[167]
N-arylglyoxamide Derivatives	LasR analog	Pyocyanin secretion	[168]
Diarylheptanoids	AHL-mediated	Production of biofilm and pyocyanin secretion	[161]
Aspirin	AHL-mediated	Virulence factor production, expressions of lasI, lasR, rhlI, rhlR, pqsA and pqsR genes and expression of Pseudomonas toxins exoS and exoY	[128]
Meloxicam and Piroxicam	AHL-mediated	LasR and PqsE protein	[129]
N-decanoyl-L-homoserine benzyl ester	AHL-mediated	Virulence factors production	[164]
3-nitro phenylacetanoyl HL	AHL-mediated	LasR reporter	[169]
1,3-benzoxazol-2(3 H)-one, 5-chloro-1,3-benzoxazol-2(3 H)-one, 6-methyl-1,3-benzoxazol-2(3 H)-one, and 5-methyl-1,3-benzoxazol-2(3 H)-one	Unknown	Elastase secretion, production of biofilm and motility phenotypes	[170]
(S,E)-2-hydroxy-N-(3-hydroxy-5-(hydroxymethyl)-2-27 methylpyridin-4-yl)propane hydrazide (pyridoxal lactohydrazone)	Unknown	Motility phenotypes, production of biofilm and pyocyanin secretion	[171]
Diastereomeric 2-methoxycyclopentyl	AHL-mediated	Pigmentation production	[172]
benzamide-benzimidazole	Transcriptional regulator	Reduced acute and persistent pathogenicity	[12]
(S,E)-2-hydroxy-N-(2-hydroxy-5-nitrobenzylidene) propane hydrazide (lacto hydrazone)	Unknown	Motility phenotypes, production of biofilm and pyocyanin secretion	[173]
Meta-bromo-thiolactone	LasR/RhlR analogs	Secretion of pyocyanin and production of biofilm	[174]