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. 2020 Aug 25;15:6409–6420. doi: 10.2147/IJN.S246659

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© 2020 Peng et al.

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Antitumor activity of MP-PTX in vitro. (A) The MTT assay was used to determine the cytotoxic effects in control, MP, PTX, and MP-PTX group at 24h, 48h and 72h. PTX and MP-PTX groups showed cytotoxicity to Hela cells when compared to the control group, and the antitumor activity of MP-PTX was better than that of PTX alone. (B) The cytotoxicity of MP-PTX against other cervical cancer cells and non-cancer cells in vitro for 48 h was evaluated by the apoptosis study. PTX and MP-PTX groups showed cytotoxicity to Hela cells, SiHa cells, and HUV-EC when compared to the control group. The cytotoxicity of MP-PTX to SiHa cells was stronger than that of PTX, and the results were the same as that of Hela cells. The cytotoxicity of MP-PTX to HUVEC was weaker than that of PTX alone (*p < 0.05, **p < 0.01).