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. 2020 Aug 21;12:7561–7568. doi: 10.2147/CMAR.S263083

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© 2020 Huang et al.

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miR-516a-5p directly targeted FBXL18. (A) Schematic illustration for the binding sites between miR-516a-5p and FBXL18. (B) Relative expression of FBXL18 in BC tissues and adjacent normal tissues. (C) Luciferase reporter assay was performed to validate the interaction between miR-516a-5p and FBXL18. (D) miR-516a-5p mimics inhibited FBXL18 expression. (E) Cell proliferation was assessed by CCK8 assay. (F and G) Transwell assay for analysis of migration and invasion. (H) EJ and T24 cells were treated with Gemcitabine (5 μM) for 24 h and then cell viability was measured by CCK8. *P<0.05.